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Animal studies in which prednisolone has been given to pregnant mice, rats, and rabbits have yielded an increased incidence of cleft palate in the offspring

All participants had a BMI 27 kg/m, established cardiovascular disease (prior MI, stroke, or peripheral artery disease), but no diabetes, making this the largest trial of a GLP-1RA in a non-diabetic, high-risk cardiovascular cohort

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Peptide stability depends on sequence, concentration, pH, buffer, excipients, surfaces, agitation, temperature, and lyophilization conditions [7]